Publications

2022

Cook, Katelyn C, Elene Tsopurashvili, Jason M Needham, Sunnie R Thompson, and Ileana M Cristea. “Restructured Membrane Contacts Rewire Organelles for Human Cytomegalovirus Infection.” Nature communications 13 (2022): 4720.
Greco, Todd, Christopher Secker, Eduardo Silva Ramos, Joel Federspiel, Jeh-Ping Liu, Alma Perez, Ismael Al-Ramahi, Jeffrey Cantle, Jeffrey Carroll, Juan Botas, Scott Zeitlin, Erich Wanker, and Ileana Cristea. “Dynamics of Huntingtin Protein Interactions in the Striatum Identifies Candidate Modifiers of Huntington Disease.” Cell Syst. 13.4 (2022): 304–320.e5. Print.
Howard, Timothy R., Krystal K. Lum, Michelle A. Kennedy, and Ileana M. Cristea. “The Nuclear DNA Sensor IFI16 Indiscriminately Binds to and Diminishes Accessibility of the HSV-1 Genome to Suppress Infection.” mSystems 7 (2022): 00198–22.
Justice, Joshua L., and Ileana M. Cristea. “Nuclear Antiviral Innate Responses at the Intersection of DNA Sensing and DNA Repair.” Trends in Microbiology 30 (2022): 1056–1071.
Kennedy, Michelle A., Matthew D. Tyl, Cora N. Betsinger, Joel D. Federspiel, Xinlei Sheng, Jesse H. Arbuckle, Thomas M. Kristie, and Ileana M. Cristea. “A TRUSTED Targeted Mass Spectrometry Assay for Pan-Herpesvirus Protein Detection.” Cell Reports 39.6 (2022): 110810.
Kennedy, Michelle A., Todd M. Greco, Bokai Song, and Ileana M. Cristea. “HTT-OMNI: A Web-Based Platform for Huntingtin Interaction Exploration and Multi-Omics Data Integration.” Molecular & Cellular Proteomics 21 (2022): 100275.
Robbe, Zachary, Wei Shi, Lauren Wasson, Angel Scialdone, Caralynn Wilczewski, Xinlei Sheng, Austin Hepperla, Brynn Akerberg, William Pu, Ileana Cristea, Ian Davis, and Frank Conlon. “CHD4 Is Recruited by GATA4 and NKX2-5 to Repress Noncardiac Gene Programs in the Developing Heart.” Genes Dev. 36.7-8 (2022): 468–482. Print.
Serrero, Manutea, Virginie Girault, Sebastian Weigang, Todd Greco, Ana Ramos Nascimento, Fenja Anderson, Antonio Piras, Ana Hickford Martinez, Jonny Hertzog, Anne Binz, Anja Pohlmann, Ute Prank, Jan Rehwinkel, Rudolf Bauerfeind, Ileana M. Cristea, Andreas Pichlmair, Georg Kochs, and Beate Sodeik. “The Interferon-Inducible GTPase MxB Promotes Capsid Disassembly and Genome Release of Herpesviruses.” Elife 11 (2022): e76804. Print.
Tyl, Matthew, Cora Betsinger, and Ileana Cristea. “Virus–host Protein Interactions As Footprints of Human Cytomegalovirus Replication.” Current Opinion in Virology 52 (2022): 135–147.

2021

Betsinger, Cora N., Connor S. R. Jankowski, William A. Hofstadter, Joel D. Federspiel, Clayton J. Otter, Pierre M. Jean Beltran, and Ileana M. Cristea. “The Human Cytomegalovirus Protein pUL13 Targets Mitochondrial Cristae Architecture to Increase Cellular Respiration During Infection.” Proceedings of the National Academy of Sciences 118.32 (2021): e2101675118.
Esposito, Mark, Cao Fang, Katelyn Cook, Nana Park, Yong Wei, Chiara Spadazzi, Dan Bracha, Ramesh Gunaratna, Gary Laevsky, Christina DeCoste, Hannah Slabodkin, Clifford Brangwynne, Ileana Cristea, and Yibin Kang. “TGF-β-Induced DACT1 Biomolecular Condensates Repress Wnt Signalling to Promote Bone Metastasis.” Nat Cell Biol 23.3 (2021): 257–267.
Howard, Timothy, Marni Crow, Todd Greco, Krystal Lum, Tuo Li, and Ileana Cristea. “The DNA Sensor IFIX Drives Proteome Alterations To Mobilize Nuclear and Cytoplasmic Antiviral Responses, With Its Acetylation Acting As a Localization Toggle.” mSystems 6.3 (2021): e0039721.
Justice, Joshua, Michelle Kennedy, Josiah Hutton, Dawei Liu, Bokai Song, Brett Phelan, and Ileana Cristea. “Systematic Profiling of Protein Complex Dynamics Reveals DNA-PK Phosphorylation of IFI16 En Route to Herpesvirus Immunity.” Sci Adv 7.25 (2021): n. pag.
Lum, Krystal, and Ileana Cristea. “Host Innate Immune Response and Viral Immune Evasion During Alphaherpesvirus Infection.” Curr Issues Mol Biol 42 (2021): 635–686.
Murray-Nerger, Laura, Joshua Justice, Pranav Rekapalli, Josiah Hutton, and Ileana Cristea. “Lamin B1 Acetylation Slows the G1 to S Cell Cycle Transition through Inhibition of DNA Repair.” Nucleic Acids Res 49.4 (2021): 2044–2064.
Murray-Nerger, Laura, and Ileana Cristea. “Lamin Post-Translational Modifications: Emerging Toggles of Nuclear Organization and Function.” Trends Biochem Sci (2021): n. pag.
Shi, Wei, Xinlei Sheng, Kerry Dorr, Josiah Hutton, James Emerson, Haley Davies, Tia Andrade, Lauren Wasson, Todd Greco, Yutaka Hashimoto, Joel Federspiel, Zachary Robbe, Xuqi Chen, Arthur Arnold, Ileana Cristea, and Frank Conlon. “Cardiac Proteomics Reveals Sex Chromosome-Dependent Differences Between Males and Females That Arise Prior to Gonad Formation.” Developmental Cell 56.21 (2021): 3019–3034.e7.
Song, Bokai, Dawei Liu, Todd Greco, and Ileana Cristea. “Post-Translational Modification Control of Viral DNA Sensors and Innate Immune Signaling.” Adv Virus Res 109 (2021): 163–199.

2020

Adhikari, Subash, Edouard Nice, Eric Deutsch, Lydie Lane, Gilbert Omenn, Stephen Pennington, Young-Ki Paik, Christopher Overall, Fernando Corrales, Ileana Cristea, Jennifer Van Eyk, Mathias Uhlén, Cecilia Lindskog, Daniel Chan, Amos Bairoch, James Waddington, Joshua Justice, Joshua LaBaer, Henry Rodriguez, Fuchu He, Markus Kostrzewa, Peipei Ping, Rebekah Gundry, Peter Stewart, Sanjeeva Srivastava, Sudhir Srivastava, Fabio Nogueira, Gilberto Domont, Yves Vandenbrouck, Maggie Lam, Sara Wennersten, Juan Antonio Vizcaino, Marc Wilkins, Jochen Schwenk, Emma Lundberg, Nuno Bandeira, Gyorgy Marko-Varga, Susan Weintraub, Charles Pineau, Ulrike Kusebauch, Robert Moritz, Seong Beom Ahn, Magnus Palmblad, Michael Snyder, Ruedi Aebersold, and Mark Baker. “A High-Stringency Blueprint of the Human Proteome.” Nat Commun 11.1 (2020): 5301.
Federspiel, Joel, Katelyn Cook, Michelle Kennedy, Samvida Venkatesh, Clayton Otter, William Hofstadter, Pierre Jean Beltran, and Ileana Cristea. “Mitochondria and Peroxisome Remodeling across Cytomegalovirus Infection Time Viewed through the Lens of Inter-ViSTA.” Cell Rep 32.4 (2020): 107943.
Greco, Todd, Michelle Kennedy, and Ileana Cristea. “Proteomic Technologies for Deciphering Local and Global Protein Interactions.” Trends Biochem Sci 45.5 (2020): 454–455.
Hartenian, Ella, Sarah Gilbertson, Joel Federspiel, Ileana Cristea, and Britt Glaunsinger. “RNA Decay During Gammaherpesvirus Infection Reduces RNA Polymerase II Occupancy of Host Promoters But Spares Viral Promoters.” PLoS Pathog 16.2 (2020): e1008269.
Hashimoto, Yutaka, Xinlei Sheng, Laura Murray-Nerger, and Ileana Cristea. “Temporal Dynamics of Protein Complex Formation and Dissociation During Human Cytomegalovirus Infection.” Nat Commun 11.1 (2020): 806.
Howard, Timothy, and Ileana Cristea. “Interrogating Host Antiviral Environments Driven by Nuclear DNA Sensing: A Multiomic Perspective.” Biomolecules 10.12 (2020): n. pag.
Kennedy, Michelle, William Hofstadter, and Ileana Cristea. “TRANSPIRE: A Computational Pipeline to Elucidate Intracellular Protein Movements from Spatial Proteomics Data Sets.” J Am Soc Mass Spectrom 31.7 (2020): 1422–1439.
Kinoshita, Noriyuki, Yutaka Hashimoto, Naoko Yasue, Makoto Suzuki, Ileana Cristea, and Naoto Ueno. “Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR Erk2 Signaling Pathway During Embryogenesis.” Cell Rep 30.11 (2020): 3875–3888.e3.
Omenn, Gilbert, Lydie Lane, Christopher Overall, Ileana Cristea, Fernando Corrales, Cecilia Lindskog, Young-Ki Paik, Jennifer Van Eyk, Siqi Liu, Stephen Pennington, Michael Snyder, Mark Baker, Nuno Bandeira, Ruedi Aebersold, Robert Moritz, and Eric Deutsch. “Research on the Human Proteome Reaches a Major Milestone: >90% of Predicted Human Proteins Now Credibly Detected, According to the HUPO Human Proteome Project.” J Proteome Res 19.12 (2020): 4735–4746.
Song, Bokai, Todd Greco, Krystal Lum, Caroline Taber, and Ileana Cristea. “The DNA Sensor CGAS Is Decorated by Acetylation and Phosphorylation Modifications in the Context of Immune Signaling.” Mol Cell Proteomics 19.7 (2020): 1193–1208.
Tanneti, Nikhila, Joel Federspiel, Ileana Cristea, and Lynn Enquist. “The Axonal Sorting Activity of Pseudorabies Virus Us9 Protein Depends on the State of Neuronal Maturation.” PLoS Pathog 16.12 (2020): e1008861.

2019

Betsinger, Cora, and Ileana Cristea. “Mitochondrial Function, Metabolic Regulation, and Human Disease Viewed through the Prism of Sirtuin 4 (SIRT4) Functions.” J Proteome Res 18.5 (2019): 1929–1938.
Bredrup, Cecilie, Tomasz Stokowy, Julie McGaughran, Samuel Lee, Dipak Sapkota, Ileana Cristea, Linda Xu, Kåre Steinar Tveit, Gunnar Høvding, Vidar Martin Steen, Eyvind Rødahl, Ove Bruland, and Gunnar Houge. “A Tyrosine Kinase-Activating Variant Asn666Ser in PDGFRB Causes a Progeria-Like Condition in the Severe End of Penttinen Syndrome.” Eur J Hum Genet 27.4 (2019): 574–581.
Carabetta, Valerie, Todd Greco, Ileana Cristea, and David Dubnau. “YfmK Is an N-Lysine Acetyltransferase That Directly Acetylates the Histone-Like Protein HBsu in.” Proc Natl Acad Sci U S A 116.9 (2019): 3752–3757.
Cook, Katelyn, Jorge Moreno, Pierre Jean Beltran, and Ileana Cristea. “Peroxisome Plasticity at the Virus-Host Interface.” Trends Microbiol 27.11 (2019): 906–914.
Cook, Katelyn, and Ileana Cristea. “Location Is Everything: Protein Translocations As a Viral Infection Strategy.” Curr Opin Chem Biol 48 (2019): 34–43.
Cristea, Ileana, and Kathryn Lilley. “Editorial Overview: Untangling Proteome Organization in Space and Time.” Curr Opin Chem Biol 48 (2019): A1-A4.
Cristea, Ileana, Pieter Dorrestein, Jonathan Eisen, Jack Gilbert, Julie Huber, Janet Jansson, Rob Knight, Katherine Pollard, Jeroen Raes, Pamela Silver, Nicole Webster, and Jian Xu. “Early-Career Scientists Shaping the World.” mSystems 4.3 (2019): n. pag.
Esposito, Mark, Nandini Mondal, Todd Greco, Yong Wei, Chiara Spadazzi, Song-Chang Lin, Hanqiu Zheng, Corey Cheung, John Magnani, Sue-Hwa Lin, Ileana Cristea, Robert Sackstein, and Yibin Kang. “Bone Vascular Niche E-Selectin Induces Mesenchymal-Epithelial Transition and Wnt Activation in Cancer Cells to Promote Bone Metastasis.” Nat Cell Biol 21.5 (2019): 627–639.
Federspiel, Joel, Todd Greco, Krystal Lum, and Ileana Cristea. “Hdac4 Interactions in Huntington’s Disease Viewed Through the Prism of Multiomics.” Mol Cell Proteomics 18.8 suppl 1 (2019): S92-S113.
Federspiel, Joel, Panna Tandon, Caralynn Wilczewski, Lauren Wasson, Laura Herring, Samvida Venkatesh, Ileana Cristea, and Frank Conlon. “Conservation and Divergence of Protein Pathways in the Vertebrate Heart.” PLoS Biol 17.9 (2019): e3000437.
Hashimoto, Yutaka, Noriyuki Kinoshita, Todd Greco, Joel Federspiel, Pierre Jean Beltran, Naoto Ueno, and Ileana Cristea. “Mechanical Force Induces Phosphorylation-Mediated Signaling That Underlies Tissue Response and Robustness in Xenopus Embryos.” Cell Syst 8.3 (2019): 226–241.e7.
Hashimoto, Yutaka, Todd Greco, and Ileana Cristea. “Contribution of Mass Spectrometry-Based Proteomics to Discoveries in Developmental Biology.” Adv Exp Med Biol 1140 (2019): 143–154.
Hernández Durán, Anna, Todd Greco, Benjamin Vollmer, Ileana Cristea, Kay Grünewald, and Maya Topf. “Protein Interactions and Consensus Clustering Analysis Uncover Insights into Herpesvirus Virion Structure and Function Relationships.” PLoS Biol 17.6 (2019): e3000316.
Howard, Timothy, Bokai Song, and Ileana Cristea. “Workflows and Considerations for Investigating Protein Interactions of Viral DNA Sensors.” Methods Enzymol 625 (2019): 309–338.
Lum, Krystal, Timothy Howard, Catherina Pan, and Ileana Cristea. “Charge-Mediated Pyrin Oligomerization Nucleates Antiviral IFI16 Sensing of Herpesvirus DNA.” mBio 10.4 (2019): n. pag.
Murray, Laura, Ashton Combs, Pranav Rekapalli, and Ileana Cristea. “Methods for Characterizing Protein Acetylation During Viral Infection.” Methods Enzymol 626 (2019): 587–620.

2018

Cho, Hyunghoon, Bonnie Berger, Jian Peng, Cyril Galitzine, Olga Vitek, Pierre Jean Beltran, Ileana Cristea, Franziska Görtler, Stefan Solbrig, Tilo Wettig, Peter Oefner, Rainer Spang, Michael Altenbuchinger, Rebecca Sarto Basso, Dorit Hochbaum, Fabio Vandin, Dana Silverbush, Simona Cristea, Gali Yanovich, Tamar Geiger, Niko Beerenwinkel, Roded Sharan, Zhemin Zhou, Nina Luhmann, Nabil-Fareed Alikhan, and Mark Achtman. “Principles of Systems Biology, No. 31.” Cell Syst 7.2 (2018): 133–135.
Gilbertson, Sarah, Joel Federspiel, Ella Hartenian, Ileana Cristea, and Britt Glaunsinger. “Changes in MRNA Abundance Drive Shuttling of RNA Binding Proteins, Linking Cytoplasmic RNA Degradation to Transcription.” Elife 7 (2018): n. pag.
Jean Beltran, Pierre, Katelyn Cook, Yutaka Hashimoto, Cyril Galitzine, Laura Murray, Olga Vitek, and Ileana Cristea. “Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication.” Cell Host Microbe 24.4 (2018): 526–541.e7.

Additional publications and collaborations

Contact

Cristea Lab
Department of Molecular Biology
210 Thomas Laboratory
Washington Road
Princeton, NJ 08544
p 609-258-9425

Faculty Assistant
Mary Gidaro
mgidaro@princeton.edu 
105 Thomas Laboratory
p 609-258-8956
f  609-258-1704

Lab Website
molbiolabs.princeton.edu/cristea