Histone deacetylases in herpesvirus replication and virus-stimulated host defense

Publication Year
2013

Type

Journal Article
Abstract

Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly, viruses have evolved a wide array of mechanisms to subvert HDAC functions. Here, we review the mechanisms underlying HDAC regulation during herpesvirus infection. We next discuss the roles of acetylation in host defense against herpesvirus infection. Finally, we provide a perspective on the contribution of current mass spectrometry-based "omic" technologies to infectious disease research, offering a systems biology view of infection.

Journal
Viruses
Volume
5
Issue
7
Pages
1607-32
Date Published
06/2013
ISSN Number
1999-4915
Alternate Journal
Viruses
PMID
23807710