@article{177286,
  keywords = {Humans, proteomics, Proteome, Disease, Human Genome Project},
  author = {Subash Adhikari and Edouard Nice and Eric Deutsch and Lydie Lane and Gilbert Omenn and Stephen Pennington and Young-Ki Paik and Christopher Overall and Fernando Corrales and Ileana Cristea and Jennifer Van Eyk and Mathias Uhl{\'e}n and Cecilia Lindskog and Daniel Chan and Amos Bairoch and James Waddington and Joshua Justice and Joshua LaBaer and Henry Rodriguez and Fuchu He and Markus Kostrzewa and Peipei Ping and Rebekah Gundry and Peter Stewart and Sanjeeva Srivastava and Sudhir Srivastava and Fabio Nogueira and Gilberto Domont and Yves Vandenbrouck and Maggie Lam and Sara Wennersten and Juan Antonio Vizcaino and Marc Wilkins and Jochen Schwenk and Emma Lundberg and Nuno Bandeira and Gyorgy Marko-Varga and Susan Weintraub and Charles Pineau and Ulrike Kusebauch and Robert Moritz and Seong Beom Ahn and Magnus Palmblad and Michael Snyder and Ruedi Aebersold and Mark Baker},
  title = {A high-stringency blueprint of the human proteome},
  abstract = {<p>The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP{\textquoteright}s tenth anniversary, we here report a 90.4\% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.</p>
},
  year = {2020},
  journal = {Nat Commun},
  volume = {11},
  pages = {5301},
  month = {10/2020},
  issn = {2041-1723},
  doi = {10.1038/s41467-020-19045-9},
  language = {eng},
}