@article{145221,
  keywords = {Animals, Humans, signal transduction, Cell Proliferation, Mice, Cell Line, Tumor, Cell Movement, Neoplasms, Epithelial-Mesenchymal Transition, Sialoglycoproteins, Transcriptional Activation, Neoplasm Metastasis, Wnt Signaling Pathway, Stem Cell Niche, Neoplastic Stem Cells, Bone Neoplasms, Xenograft Model Antitumor Assays, E-Selectin, Fucosyltransferases, Receptors, Fibroblast Growth Factor},
  author = {Mark Esposito and Nandini Mondal and Todd Greco and Yong Wei and Chiara Spadazzi and Song-Chang Lin and Hanqiu Zheng and Corey Cheung and John Magnani and Sue-Hwa Lin and Ileana Cristea and Robert Sackstein and Yibin Kang},
  title = {Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis},
  abstract = {<p>How disseminated tumour cells engage specific stromal components in distant organs for survival and outgrowth is a critical but poorly understood step of the metastatic cascade. Previous studies have demonstrated the importance of the epithelial-mesenchymal transition in promoting the cancer stem cell properties needed for metastasis initiation, whereas the reverse process of mesenchymal-epithelial transition is required for metastatic outgrowth. Here we report that this paradoxical requirement for the simultaneous induction of both mesenchymal-epithelial transition and cancer stem cell traits in disseminated tumour cells is provided by bone vascular niche E-selectin, whose direct binding to cancer cells promotes bone metastasis by inducing mesenchymal-epithelial transition and activating Wnt signalling. E-selectin binding activity mediated by the α1-3 fucosyltransferases Fut3/Fut6 and Glg1 are instrumental to the formation of bone metastasis. These findings provide unique insights into the functional role of E-selectin as a component of the vascular niche critical for metastatic colonization in bone.</p>
},
  year = {2019},
  journal = {Nat Cell Biol},
  volume = {21},
  pages = {627-639},
  month = {05/2019},
  issn = {1476-4679},
  doi = {10.1038/s41556-019-0309-2},
  language = {eng},
}