@article{132006,
  keywords = {Animals, Humans, Transcription Factors, Cell Line, Mice, Epithelial Cells, Genes, Immediate-Early, Gene Expression Regulation, Viral, Virus Activation, Simplexvirus, Ganglia, Sensory, Host Cell Factor C1, Transcription Elongation, Genetic},
  author = {Roberto Alfonso-Dunn and Anne-Marie Turner and Pierre Jean Beltran and Jesse Arbuckle and Hanna Budayeva and Ileana Cristea and Thomas Kristie},
  title = {Transcriptional Elongation of HSV Immediate Early Genes by the Super Elongation Complex Drives Lytic Infection and Reactivation from Latency},
  abstract = {<p>The cellular transcriptional coactivator HCF-1 is required for initiation of herpes simplex virus (HSV) lytic infection and for reactivation from latency in sensory neurons. HCF-1 stabilizes the viral Immediate Early (IE) gene enhancer complex and mediates chromatin transitions to promote IE transcription initiation. In infected cells, HCF-1 was also found to be associated with a network of transcription elongation components including the super elongation complex (SEC). IE genes exhibit characteristics of genes controlled by transcriptional elongation, and the SEC-P-TEFb complex is specifically required to drive the levels of productive IE mRNAs. Significantly, compounds that enhance the levels of SEC-P-TEFb also potently stimulated HSV reactivation from latency both in a sensory ganglia model system and in\&nbsp;vivo. Thus, transcriptional elongation of HSV IE genes is a key limiting parameter governing both the initiation of HSV infection and reactivation of latent genomes.</p>
},
  year = {2017},
  journal = {Cell Host Microbe},
  volume = {21},
  pages = {507-517.e5},
  month = {04/2017},
  issn = {1934-6069},
  doi = {10.1016/j.chom.2017.03.007},
  language = {eng},
}